New way to improve antibiotic production
June 17, 2013 — An antibiotic has been found to stimulate its own production. The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.
Scientists Dr Emma Sherwood and Professor Mervyn Bibb from the John Innes Centre were able to use their discovery of how the antibiotic is naturally produced to markedly increase the level of production.
"We have shown for the first time that an antibiotic with clinical potential can act as signalling molecule to trigger its own synthesis," said Professor Bibb.
The antibiotic called planosporicin is produced by a soil bacterium called Planomonospora alba. When nutrients become limited, a small amount of the antibiotic is produced. The antibiotic is then able to trigger a mechanism which coordinates its own production throughout the bacterial population resulting in high levels.
"A frequent stumbling block in developing a natural product for commercialisation is being able to provide enough material for clinical trials," said Professor Bibb.
"Our work shows with the right understanding it is possible to increase productivity very dramatically in a targeted and knowledge-based manner."
With knowledge of this signalling mechanism in hand, the scientists were able to increase production by overexpressing two positively acting regulatory genes and deleting one that acts negatively. Planosporicin is similar to the antibiotic NAI-107 that is about to enter clinical trials for Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) infections. The knowledge gained from this study is being used to increase NAI-107 production.
Commercial manufacturers of antibiotics may be able to use the results to reduce production times and therefore reduce costs. Bacteria often have to be grown for days and sometimes weeks before they start to make effective amounts of an antibiotic. Sherwood and Bibb were able to trigger production essentially from the beginning of growth.
The work was funded through JIC's core strategic grant from the Biotechnology and Biological Sciences Research Council.
Welcome to SUV System Ltd!
SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.
We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.
SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com
Electronic Components distributor:http://www.suvsystem.com
Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html
IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html
LED Distributor:http://www.suvsystem.com/l/LED-1.html
Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html
Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html
Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html
Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html
SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc
we are focus on the following fields,and hope we can help you.
C0603X562M2RAL7210 C0603X562M1RALTU C0603X562M1RAL7210 C0603X562K9RALTU C0603X562K9RAL7411 C0603X562K8RALTU C0603X562K8RAL7411 C0603X562K5RALTU C0603X562K5RAL7411 C0603X562K5RAC C0603X562K4RALTU C0603X562K4RAL7411 C0603X562K3RALTU C0603X562K3RAL7411 C0603X562K2RALTU C0603X562K2RAL7411 C0603X562K2RACTU C0603X562K1RALTU C0603X562K1RAL7411 C0603X562J9RALTU C0603X562J9RAL7411 C0603X562J8RALTU C0603X5R0J103K C0603X5R0G105M C0603X563M9RALTU C0603X563M9RAL7210 C0603X563M8RALTU C0603X563M8RAL7210 C0603X563M5RALTU C0603X563M5RAL7210 C0603X563M4RALTU C0603X563M4RAL7210 C0603X563M3RALTU C0603X563M3RAL7210 C0603X563K9RALTU C0603X563K8RALTU C0603X563K8RAL7411 C0603X563K5RALTU C0603X563K5RAL7411 C0603X563K5RAC
http://www.suvsystem.com/a/2904.aspx
