Mice give new clues to origins of obsessive-compulsive disorder
OCD consists of obsessions, which are recurrent intrusive thoughts, and compulsions, which are repetitive behaviors that patients perform to reduce the severe anxiety associated with the obsessions. The disorder affects 2-3 percent of people worldwide and is an important cause of illness-related disability, according to the World Health Organization.
Using a new technology in a mouse model, the researchers found that repeated stimulation of specific circuits linking the brain's cortex and striatum produces progressive repetitive behavior. By targeting this region, it may be possible to stop abnormal circuit changes before they become pathological behaviors in people at risk for obsessive-compulsive disorder (OCD). The study, which was led by Susanne Ahmari, MD, PhD, assistant professor of clinical psychiatry at Columbia Psychiatry and the New York State Psychiatric Institute, was published in the June 7 issue of Science.
While the obsessions and compulsions that are the hallmarks of OCD are thought to be centered in the cortex, which controls thoughts, and the striatum, which controls movements, little is known about how abnormalities in these brain regions lead to compulsive behaviors in patients.
To simulate the increased activity that takes place in the brains of OCD patients, Dr. Ahmari and her colleagues used a new technology called optogenetics, in which light-activated ion channels are expressed in subsets of neurons in mice, and neural circuits are then selectively activated using light delivered through fiberoptic probes.
"What we found was really surprising," said Dr. Ahmari. "That activation of cortico-striatal circuits did not lead directly to repetitive behaviors in the mice. But if we repeatedly stimulated for multiple days in a row for only five minutes a day, we saw a progressive development of repetitive behaviors -- in this case, repetitive grooming behavior -- that persisted up to two weeks after the stimulation was stopped."
She added, "And not only that, when we treated the mice with fluoxetine, one of the most common medications used for OCD, their behavior went back to normal." The current study, as well as others currently being performed by Dr. Ahmari and her team, may ultimately provide clues for new treatment targets in terms of both novel drug development and direct stimulation techniques, including deep brain stimulation (DBS).
The study was supported by grants from NIMH (K08MH087718; K24 MH091555), the Louis V. Gerstner, Jr. Scholars Program, the Irving Institute for Clinical and Translational Research, the Gray Matters Foundation, the Leon Levy Foundation, and a NARSAD Young Investigator Award.
Welcome to SUV System Ltd!
SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.
We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.
SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com
Electronic Components distributor:http://www.suvsystem.com
Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html
IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html
LED Distributor:http://www.suvsystem.com/l/LED-1.html
Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html
Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html
Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html
Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html
SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc
we are focus on the following fields,and hope we can help you.
CMF5568K100FKEA70 CMF5568K100FKEA CMF5568K100FKBF70 CMF5568K100FKBF CMF5568K100FHRE CMF5568K100FHEK CMF5568K100FHEB CMF5568K100FHEA CMF5568K100FEEK CMF5568K100FEBF CMF5568K100DHWF CMF5568K100DHRE CMF5568K100DHR8 CMF5568K100DHR7 CMF5568K100DHR6 CMF5568K100DHEB CMF5568K100DHEA CMF5568K100BHWF CMF5568K100BHRE CMF5568K100BHR8 CMF5568K100BHR7 CMF5568K100BHR6 CMF5568K100BHEB CMF5568K100BHEA CMF5568K100BEWF CMF5568K100BERE CMF5568K100BER8 CMF5568K100BER7 CMF5568K100BER670 CMF5568K100BER6 CMF5568K100BEEK CMF5568K100BEEB CMF5568K100BEEA CMF5568K100BEBF CMF5568R100FKWF CMF5568R100FKRE CMF5568R100FKR8 CMF5568R100FKR7 CMF5568R100FKR6 CMF5568R100FKEK39
http://www.suvsystem.com/a/2464.aspx
